Cellular Systems Dynamics Group PI : Oleg Igoshin


Rice University
Department of Bioengineering - MS142
P.O. Box 1892
Houston, Texas 77251-1892

Office: BRC 767

Group: BRC750E





- Bioengineering Department
- Rice University
Rice Systems and Synthetic Biology Group

(Last modified
October, 2012)

Selected Publications (PDF reprints  below for educational use)

  1. Igoshin O.A., Mogilner A., Welch R.D., Kaiser D., Oster G., Pattern formation and traveling waves in myxobacteria: Theory and modeling, PNAS, 98 (2001)14913-14918 [reprint].
  2. Wolgemuth C.W., Igoshin O., Oster G., The motility of mollicutes, Biopys. J., 85 (2003) 828-842 [reprint]
  3. Igoshin, O. A., Welch R., Kaiser D., Oster G.., Waves and aggregation patterns in myxobacteria, PNAS, 101(2004) 4256-4261 [reprint]
  4. Igoshin, O.A., Kaiser, D., Oster G. Symmetry breaking in myxobacteria, Curr. Biol 14(2004) R459-R462 [reprint]
  5. Igoshin, O.A., Goldbeter A., Kaiser, D., Oster G. A biochemical oscillator explains several aspects of M.  xanthus behavior during development, PNAS 101(2004) 15760-15765 [reprint]
  6. Igoshin, O. A., Price, C.W., Savageau, M.A., Signaling network with a bistable hysteretic switch controls developmental activation of the sigma transcription factor in Bacillus subtilis, Mol. Microbiol. 61 (2006)165-184  [reprint]
  7. Igoshin, O. A., Brody, M.S., Price, C.W., Savageau, M.A., Distinctive topologies of partner-switching signaling networks correlate with their physiological roles  Jour. Mol. Biol., 369(2007):1333-52 [reprint]
  8. Veening, J-W, Igoshin, O.A., Eijlander, R.T., Hamoen, L.W., Nijland, R. and Kuipers, O.P. Transient heterogeneity in extracellular protease production by Bacillus subtilis., Molecular Systems Biology, (2008) 4-184 [reprint]
  9. Igoshin, O.A., Alves, R. and Savageau, M.A., Hysteretic and graded responses in bacterial two-component signal transduction, Molecular Micorbiology, 68 (2008): 1196–1215  [reprint]
  10. Chaudhury,  S. and  Igoshin, O.A., Dynamic disorder-driven substrate inhibition and bistability in a simple enzyme catalysis reaction,  J Phys Chem B, 113 (2009): 13421-8 [reprint]
  11. Ray, J.C.J. and Igoshin, O.A. Lifestyle-optimized transcriptional feedback in bacterial two-component signaling,  PLoS Comp Biol , 6(2) (2010): e1000676 [reprint]
  12. Eswaramoorthy, P, Dinh, D, Dunn, D., Igoshin, O.A. and Fujita, M., Single cell measurement of the levels and distributions of the phosphorelay components in a population of sporulating Bacillus subtilis cells, Microbiology ,156  (2010): 2294 - 2304 [reprint]
  13. Narula, J., Smith, A.M. Gottgens B., Igoshin, O.A., Modeling Reveals Bistability and Low-Pass Filtering in the Network Module Determining Blood Stem Cell Fate, PLoS Comput Biol 6(5) (2010): e1000771  [reprint]
  14. Tiwari,  A., Balazsi, G., Gennaro, M.L. and  Igoshin, O.A., Interplay of Multiple Feedbacks with Post-Translational Kinetics Results in Bistability of Mycobacterial Stress-Response Network,  Physical Biology, 7 (2010) 036005 [reprint]
  15. Chaudhury,  S. and  Igoshin, O.A., Dynamic disorder in rapid-equilibrium enzymatic system, PLoS One, 5 (2010): e12364  [reprint]
  16. Narula, J., and Igoshin, O.A., Thermodynamic models of combinatorial gene regulation by distant regulatory elements, IET System Biology, 4(2010): 393-408 [reprint]
  17. Xie S., Zhang, H., Shimkets, L. and Igoshin, O.A. , Statistical image analysis reveals features affecting fates of Myxococcus xanthus developmental aggregates, PNAS, 108(2011): 5915-5920 [reprint]
  18. Tiwari,  A., Ray, J.C.J., Narula, J., and  Igoshin, O.A., Bistable responses in bacterial genetic networks: designs and dynamical consequences, Mathematical Bioscience, 231(2011) : 76-89  [reprint]
  19. Zhang, H., Angus, S., Tran, M., Xie S., Igoshin*, O.A. and Welch*, R.D , Quantifying aggregation dynamics during Myxococcus xanthus development, J Bacteriol., 193 (2011): 5164-70 [reprint]
  20. Ray, J.C.J., Tabor, J.J. and Igoshin, O.A., Non-transcriptional regulation shapes relationships between bacterial network structure and function, Nature Reviews Microbiology,  9 (2011): 817-828 [reprint]
  21.  Ray, J.C.J. and Igoshin, O.A., Interplay of Noisy Gene Expression and Ultrasensitive Dynamics Influences Bacterial Operon Organization, PLoS Comp Bio (2012), 8:e1002672. [reprint]
  22. Tiwari, A., and Igoshin, O.A., Coupling between feedback loops in autoregulatory networks affects bistability range, open-loop gain and switching times, Physical Biology (2012) Phys. Biol. 9: 055003. [reprint]
  23. Zhang, H., Vaksman, Z., Litwin D., Shi P., Kaplan H., Igoshin, O.A The Mechanistic Basis of Myxococcus xanthus Rippling Behavior and Its Physiological Role during Predation, PLoS Comp Biology (2012), 8: e1002715. [reprint]

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Full list of publications in PDF format is here