Welcome to Dr. Igoshin's Group in the Bioengineering Department
The ability of cells to respond to environmental stimuli with differential expression of certain genes is a key to the diversity of life. The dynamic and functional properties of such responses can only be understood by studying the organization of underlying signaling and genetic networks. We use interdisciplinary methods of nonlinear dynamics, bioinformatics and theoretical biophysics methods to characterize quantitatively the design and behavior of biochemical and gene networks and the resulting phenotypes.
In particular, we are interested in:
- Evolutionary design principles of master level gene expression regulation in bacteria
- Organization and evolution of intercellular signaling networks in bacterial communication and development
- Spatial organization, dynamics and metabolism in bacterial communities