1. 1.Zhao W, Bonem M, McWhite C, Silberg JJ, Segatori L. The Deg-On system: a mammalian synthetic gene circuit to quantify proteasomal degradation. Nature Communications. In revision.

  2. 2.Lee SS, Song W, Cho M, Puppala HL, Nguyen P, Zhu H, Segatori L, Colvin VL. Antioxidant properties of cerium oxide nanocrystals as a function of nanocrystal diameter and surface coating. ACS Nano 2013 Nov 26;7(11):9693-703. doi: 10.1021/nn4026806. (pdf)

  3. 3.Mauri V, Segatori L, Sardiello, M. A rapid and sensitive method for measuring N-acetylglucosaminidase activity in cultured cells. PLoS ONE. July 2013. 8(6):e68060. doi: 10.1371/journal.pone.0068060. (pdf)

  4. 4.Kilpatrick K, Novoa JA, Hancock T, Guerriero CJ, Wipf P, Brodsky JL, Segatori L. Chemical induction of Hsp70 reduces alpha-synuclein aggregation in neuroglioma cells. ACS Chemical Biology. Apr 2013. doi: 10.1021/cb400017h. (pdf)

  5. 5.Wang F and Segatori L. Remodeling the proteostasis network to rescue glucocerebrosidase variants by inhibiting  ER-associated degradation and enhancing ER folding. PLoS ONE. Apr 2013 19;8(4):e61418. doi: 10.1371/journal.pone.0061418. (pdf)

  6. 6.Song W, Wang F, Savini M, Ake A, Di Ronza A, Sardiello M, Segatori L. TFEB regulates lysosomal proteostasis. Human Molecular Genetics 2013.  May 15;22(10):1994-2009. doi: 10.1093/hmg/ddt052. Epub 2013 Feb 7. Journal cover. (pdf)


  1. 5.Cook NP, Kilpatrick K, Segatori L, Marti AA. Detection of a-synuclein amyloidogenic aggregates in vitro and in cells using light-switching dipyridophenazine ruthenium(II) complexes. Journal of the American Chemical Society 2012 Dec 26;134(51):20776-82. (pdf)

  2. 6.Kothawala A, Kilpatrick K, Novoa JA, Segatori L. Quantitative analysis of alpha-synuclein solubility in living cells using split GFP complementation. PLoS One 2012;7(8):e43505. doi: 10.1371/journal.pone.0043505. (pdf)

  3. 7.Wang J, AlMakhaita M Biswal S, Segatori L. Sensitive detection of TNT using competition assay on quartz crystal microbalance. Biosensors and Bioelectronics 2012. 3:115. doi:10.4172/2155-6210.1000115 (pdf)

  4. 8.Mathieu JM, Wang F, Segatori L, Alvarez PJ. Increased resistance to oxysterol cytotoxicity in fibroblasts transfected with a lysosomally targeted Chromobacterium oxidase. Biotechnology and Bioengineering 2012 Sep;109(9):2409-15. doi: 10.1002/bit.24506. (pdf)


  1. 9.Wang F, Song W, Brancati G, Segatori L. Inhibition of Endoplasmic Reticulum-associated Degradation Rescues Native Folding in Loss of Function Protein Misfolding Diseases.  Journal of Biological Chemistry 2011 Dec 16;286(50):43454-64. (pdf)

  2. 10. Wang F, Chou A, Segatori L. Lacidipine remodels protein folding and Ca 2+ homeostasis in Gaucher's disease fibroblasts: a mechanism to rescue mutant glucocerebrosidase. Chemistry and Biology. 2011 Jun 24;18(6):766-76. (pdf)

  3. 11. Wang F, Agnello G, Sotolongo N, Segatori L. Ca2+ homeostasis modulation enhances the amenability of L444P glucosylcerebrosidase to proteostasis regulation in patient-derived fibroblasts. ACS Chemical Biology 2011 Feb 18;6(2):158-68. (pdf)

2010 and prior

  1. 12.Arredondo S, Segatori L, Gilbert HF, Georgiou G. De novo design and evolution of artificial disulfide isomerase enzymes analogous to the bacterial DsbC. Journal of Biological Chemistry 2008 Nov 14;283(46):31469-76. (pdf)

  2. 13.Mu TW, Ong DS, Wang YJ, Balch WE, Yates JR 3rd, Segatori L, Kelly JW. Chemical and biological approaches synergize to ameliorate protein-folding diseases. Cell 2008 Sep 5;134(5):769-81. (pdf)

  3. 14.Segatori L, Murphy L, Arredondo S, Kadokura H, Gilbert H, Beckwith J, Georgiou G. Conserved role of the linker alpha-helix of the bacterial disulfide isomerase DsbC in the avoidance of misoxidation by DsbB. Journal of Biological Chemistry 2006 Feb 24;281(8):4911-9. (pdf)

  4. 15.Georgiou G, Segatori L. Preparative expression of secreted proteins in bacteria: status report and future prospects. Current Opinion in Biotechnology 2005 Oct;16(5):538-45. Review. (pdf)

  5. 16.Zhang M, Monzingo AF, Segatori L, Georgiou G, Robertus JD. Structure of DsbC from Haemophilus influenzae. Acta Crystallographica D: Biological Crystallography 2004 Sep;60(Pt 9):1512-8. (pdf)

  6. 17.Segatori L, Paukstelis PJ, Gilbert HF, Georgiou G. Engineered DsbC chimeras catalyze both protein oxidation and disulfide-bond isomerization in Escherichia coli: Reconciling two competing pathways. Proceeding of the National Academy of Sciences U S A 2004 Jul 6;101(27):10018-23. (pdf)