Welcome to the Cell and Protein Engineering Research Laboratory at Rice.

Our ultimate goal is to study and engineer the cellular networks that maintain protein homeostasis for applications in biomedicine and bionanotechnology.

Our research focuses on:

•    deciphering the relationship between protein misfolding and disease

  1.    manipulating cellular pathways that regulate protein degradation

  2.    engineering clearance of toxic cellular substrates

  3.    understanding the interaction of engineered nanoparticles with cells

  4.    identifying the design rules to generate nanoparticles that enhance cellular clearance


Our laboratory is involved in both fundamental and applied research and it is highly multi-disciplinary, working at the interface between chemical engineering and biology. Anyone interested in more information or in a research position in the lab should contact Dr. Laura Segatori (segatori@rice.edu).

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