BIOE 425/625 

Pharmaceutical Engineering Schedule

Spring 2007

GRB 211 W

Tues/Thurs 1:00 –2:15

INSTRUCTOR

Carolyn A. Nichol, Ph.D.

Office:  Ryon 111

cnichol@rice.edu  -best way to reach me

Office hours Tue/Thur  12-1  PM

Email to schedule a meeting 

 

Teaching assistant

TA:                 Vittal Raman Srinivas   vrs4929@rice.edu

           

Week

Dates

Topic

Chapter

1

1/9/07

 

 

1/11/07

 

Overview of Course

LECTURE 1    Introduction to Pharmaceutical Engineering

 Economics and the Pharmaceutical Industry

LECTURE 2    Clinical Pharmacology

Pharmacokinetics Modeling:    IV bolus

Homework 1 assigned (Ethics and Economics)

1

 

 

 

2

2

1/16/07

 

 

1/18/07

LECTURE 3    Pharmacokinetics Modeling:    Infusion repetitive IV dosing

 

LECTURE 4    Pharmacokinetics:  Distribution, Multicompartmental modeling

Homework 1 Due (Ethics and Economics) Discussion

Homework 2 Assigned (IV bolus, AUC, elimination rates, Infusion)

2

 

 

3

3

1/23/07

 

 

1/25/07

LECTURE 5    Pharmacokinetics:  GI physiology, oral dosing, bioavailability)

 

LECTURE  6   Pharmacokinetics:  Multiple dosing Oral

Homework 2 Due (IV bolus, AUC, elimination rates)
Homework 3 Assigned (Multicompartmental modeling, oral dosing)

4

 

 

4

4

1/30/07

 

 

2/1/07

 

LECTURE 7   Pharmacokinetics: Renal physiology, drug clearance

 

LECTURE 8  Pharmacokinetics:  Hepatic physiology, drug metabolism

Homework 3 Due Multicompartmental modeling, oral dosing)

Homework 4 Assigned

5,6

 

 

7, 11

 

5

2/6/07

 

 

2/8/07

LECTURE 9 Pharmacokinetics:  Transport mechanisms, physiochemical issues

 

LECTURE 10   Pharmacokinetics: Nonlinear models Alcohol

Homework 4 Due

Homework 5 Assigned

14, Kwon, Younggil

 

6

2/13/07

 

 

2/15/06

LECTURE 11   Noncompartmental methods, Population Pharmacokinetics

 

LECTURE 12   Vaccines Dr. Berma Kinsey, Baylor

Homework 5 Due

Homework 6 assigned

8, 10

7

2/20/07

 

 

2/22/07

LECTURE 13 Metabolism & drug interactions, herbal meds, alternative medicines

 

LECTURE 14  Pharmacodynamics :  Dose Response

15

 

 

18,19

8

2/27/07

 

 

3/1/07
LECTURE 15 Introduction to Pharmaceutics and drug development

 

LECTURE 16  Preformulation, Manufacturing

Homework 6 due

28

 

 

29, 30

9

3/6/07

 

3/8/07

 

SPRING BREAK!!

 

10

 

3/13/07

 

 

 

3/15/07

LECTURE 17  Molecular Imaging and Targeted Drug Delivery Chun Li, PhD MDACC

Research Projects DUE

 

LECTURE 18 Targeted delivery

Homework 7 assigned

 

 

Phage display

 

11

3/20/07

 

 

3/22/07

 Pharmaceutical law David Matthews

http://www.drug-litigation-attorneys.com/Bio/DavidMatthews.asp

 

Pharmaceutical Law

 

 

 

 

12

3/27/07

 

3/29/07

 

Round Table Project Discussions

 

Round Table Project Discussions

 

13

4/4/07

 

4/6/07

LECTURE 19 Drug Delivery

 

No SCHOOL

 

handout 

14

4/10/07

 

4/12/07

 

LECTURE 20:  Biotechnology product development

 

LECTURE 21: Anti Cancer Agents

32

 

15

4/17/07

 

4/19/07

Group project presentations

 

Group project presentations

 

 

16

4/24/07

 

 

5/2/07

5/4/07

5/7/07

LAST CLASS  Review for Take Home Final

Homework 7 due

 

Final Exam Deadline for Graduating Students (noon)

Grades to Registrar for Graduating Seniors

Final Exam Deadline for Nongraduating students

 

 

Any student with a disability requiring accommodations in this class is encouraged to contact the instructor after class or during office hours. Additionally, students should contact the Coordinator for Disabled Student Services in the RMC Cloisters.